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14. 06. 19

Androgenetic alopecia (pattern hair loss)

    AGA or pattern hair loss is the most common hair loss in men and women. Clinical characteristics include a reduction of terminal hair density on the scalp that follows a typical pattern in both genders, with a conversion of terminal to vellus-like hairs and an increase of telogen hair (in an episode of active shedding).

    Male pattern hair loss results from a combination of androgen and genetics. Its pattern will develop with recession of the frontal hairline to M-shaped and can be classified by Norwood-Hamilton classification. Ethnic variation in the incidence has been reported. Caucasian has higher incidence than Asian and African.

    Female pattern is age-related. 40% of Caucasian women have developed some degree of this hair loss at age 70 but less frequent in Asian women, presented with a diffuse loss of hair on the crown and persistence of the frontal hairline.

     Patient history and physical exam usually give a definite diagnosis. In young women, further investigations are recommended to rule out other diseases.

     Currently, two medications are approved for the treatment of AGA: oral finasteride and topical minoxidail. However, hair restoration or hair transplantation is the most successful and permanent treatment for AGA.  

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14. 04. 17

Roles of Platelet-Rich Plasma in promation of hair follicle reconstitution

     During the past several years, Platelet-Rich Plasma (PRP) has been introduced worldwide to medical treatment for its potential not only for speeding up the healing process both acute and chronic conditions such as in bone and joint injuries, but also for rejuvenating the skin.

     Platelet-Rich Plasma (PRP) is from patient's own blood which contain 5-10 times greater of platelets and growth factors than normal.  After a simple blood draw, blood will be spun down in a special centrifuge machine to separate and concentrate platelets and growth factors from other components.

     A study from Nanfang Hospital, China, investigated the effects of Platelet-Rich Plasma (PRP) on hair follicle reconstitution in mice.  The study has found that PRP shortened the time of hair formation from 20 days to 18 days and the number of new hair follicles was also significantly increased, in 10% PRP(344+/-27 hair follicles formed), compared with 0% PRP (288+/-35 hair follicles formed)

     However, due to the inadequacy in evidence of PRP, further study is necessary.  Therefore, current therapeutic treatments of androgenic-tic alopceia are still medication and hair transplantation.

References: Yong M, Ya-Bin S, Promotional Effect of Platelet-Rich Plasma on Hair follicle Reconstitution in viva Demerol Surg.2013,39:1868-1876

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